2018•Journal of Immunological MethodsRequires access

CRISPR/Cas9 generated human CD46, CD55 and CD59 knockout cell lines as a tool for complement research

Astrid J.F. Thielen, Iris M. van Baarsen, Marlieke L.M. Jongsma, Sacha Sergio Zeerleder, Robbert M. Spaapen, Diana Wouters

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Key concepts: CD59, CD46, Complement system, Complement membrane attack complex, Atypical hemolytic uremic syndrome, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, Flow cytometry