2000•Unpublished venueRequires access
Gene expression pattern Hoxa4 expression in developing mouse hair follicles and skin
Alan I. Packer, Dan Jane‐wit, Leon P. McLean, Andrey A. Panteleyev, Angela M. Christiano, Debra J. Wolgemuth
Open publisher page 0 citations
Abstract
AbstractWe have examined the expression of the Hoxa4 gene in embryonic vibrissae and developing and cycling postnatal pelage hair follicles bydigoxigenin-based in situ hybridization. Hoxa4 expression is first seen in E13.5 vibrissae throughout the follicle placode. From E15.5 toE18.5 its expression is restricted to Henle’s layer of the inner root sheath. Postnatally, Hoxa4 expression is observed at all stages ofdeveloping pelage follicles, from P0 to P4. Sites of expression include both inner and outer root sheaths, matrix cells, and the interfollicularepidermis. Hoxa4 is not expressed in hair follicles after P4. Hoxb4, however, is expressed both in developing follicles at P2 and in catagen atP19, suggesting differential expression of these two paralogous genes in the hair follicle cycle. q 2000 Elsevier Science Ireland Ltd. Allrights reserved. Keywords: Hoxa4; Hoxb4; Hox genes; Hair follicle; Outer root sheath; Henle’s layer; Inner root sheath; Matrix; Dermal papilla; Skin; In situ hybridization