The Differences Level Of Brain Derived Neurothropic Factor (Bdnf) Hipocampus Wistar In Rats Are Given Physical Exercise Aerobic 1 Times A Week

Introduction: Physical exercise aerobically can increase the production of growth factors such as Brain Derived Neurothropic Factor (BDNF). BDNF plays a role in the process of neurogenesis with a positive impact on cognitive function. This study aims to determine whether there is a relationship between levels Neurothropic Brain Derived Factor (BDNF) in rats fed aerobic exercise and aerobic exercise are not given. Methods : This study is an experimental research laboratory with post test only control group design. The subject of research in the form of Rattus norvegicus Wistar strain amounted to 35 rats were divided into one control group and the treatment group, namely; aerobic exercise group with a frequency of 1 time per week of physical exercise done using animal treadmill at a speed of 20m / min for 30 minutes of aerobic physical exercise. Results : An increase in BDNF levels of hippocampal tissue both in aerobic exercise group (133.4 ± 2,97pg / mL) compared with the control group (55.27 ± 4.18 pg / mL). Conclusion : There is a difference between the levels of BDNF hippocampal tissue in mice fed aerobic exercise compared with control mice. Keywords : physical exercise, BDNF, Brain Tissue