Enantioselective Synthesis of F-Ring Fragments of Kibdelone C via Desymmetrizing Bromolactonization of 1,4-Dihydrobenzoic Acid

We previously reported a bifunctional organic catalyst that promotes highly efficient enantioselective halolactonizations of a broad array of olefinic acids. As part of that work, we demonstrated the desymmetrization of a prochiral substrate through a catalytic enantioselective halolactonization, and we report herein the application of one such desymmetrization process to the syntheses of F-ring subunit synthons of (+)-kibdelone C.