2018•International Journal of Livestock ResearchOpen access
Evaluation of Hematological, Serum Biochemical and Tissue Antioxidant Changes in Experimentally Induced Hyperlipidemia in Wistar Albino Rats
H. Srinivasa Naik, Ch. Srilatha, K. Sujatha, B. Sreedevi, Thottethodi Subrahmanya Keshava Prasad
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Abstract
Hyperlipidemia is the disorder of lipid metabolism, characterized by elevated serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoproteins cholesterol (VLDL-C) and decreased high density lipoprotein cholesterol (HDL-C). The present study was carried out by procuring 24 Wistar albino rats, divided into two groups consisting of 12 rats in each group. Hyperlipidemia was induced by hyperlipidemic diet consisting of 1% cholesterol and 15% saturated oil added to the 1000g of standard rat diet and given to group II rats. Group I kept as control and fed with standard rat diet. Sacrifice of the rats was done on 45th and 90th day of the experiment and six rats from each group were randomly selected for sacrifice. Group II rats clinically showed obesity with significant increase (p