Study of Efficacy of Sublingual Immunotherapy in Cases Asthma & Allergic Rhinitis in India

Purpose: To asses efficacy of sublingual immunotherapy (SLIT) in treatment severe persistent allergic rhinitis in the age group from 7 years to 63 years of either sex. Material & Method: 310 patient of severe persistent allergic rhinitis were included to assess efficacy of sublingual immunotherapy (SLIT). These patients were regular in treatment for more than 36 months. Symptom score were recorded on regular intervals 1st at the beginning of SLIT, then a completion of 1st maintenance vial i.e 3rd vial then at every next maintenance vial. All patient follow up done about 4 to 5 times during sublingual immunotherapy ( SLIT) at regular intervals. Rescue meditations for exacerbations of symptom during pollen season were also taken in to account. Number of aeroallergens included ranges from average of 2 to 4 allergens. Glycerinated aqueous allergenic extract from various allergens were taken as per their sensitivity pattern. Different Allergens extracts suspended in extracting fluid (coca solution) containing 50% Glycerine i.p. according to w/v ratio. Usual concentrations were initiation 1:500, build up 1:250, maintenance 1:100, 1:50, 1:20, 1:10. Result: In above study results were encouraging. In symptom score scale of 0 to 3. ( 0 no symptoms, 1 mild, 2 moderate, 3 severe) Number of rescue medications along with SLIT was remarkably reduced even during pollen season. Conclusion: Sublingual immunotherapy showing promising results in cases of Asthma & allergic Rhinitis