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2017•The Journal of Organic ChemistryRequires access

Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol

Ren‐Jin Tang, Thierry Milcent, Benoı̂t Crousse

Open publisher page 175 citations

Abstract

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.

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What this paper is about

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.

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Available abstract

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.

Key concepts: Halogenation, Regioselectivity, Chemistry, Organic chemistry, Suzuki reaction, Combinatorial chemistry, Catalysis, Palladium

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