2017•Bioorganic & Medicinal ChemistryOpen access

Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers

Takuya Kumamoto, Marie Nakajima, Reina Uga, Naoko Ihayazaka, Haruna Kashihara, Kazuaki Katakawa, Tsutomu Ishikawa, Ryotaro Saiki, Kazuhiro Nishimura, Kazuei Igarashi

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Key concepts: Memantine, NMDA receptor, Chemistry, Moiety, Pharmacology, Guanidine, Polyamine, Glutamate receptor