2012•Unpublished venueRequires access
Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
Márcio Cerqueira de Almeida, Sônia Gumes Andrade
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Abstract
Introduction: Treatment of Chagas disease, determined by infection with Trypanosoma cruzi has been a
challenge due to the different susceptibility of the parasite strains, characterized into different biological
types or Biodemes. It has been shown that the Benznidazole (BZ) is the drug of choice for the treatment
in humans but the results are irregular in patients of different endemic areas. Experimental data have
shown a high resistance of the strains of Biodeme type III (T. cruzi I), and irregular results in the
treatment of infections with Type II strains (T. cruzi II). The same results were obtained in the treatment
with Nifurtimox (NF), in respect to the resistance of different strains. Other drugs in clinical use for
different diseases have been assayed experimentally as the case of the Cetoconazole (Ceto). Probably
the association of different drugs could improve the results of treatment in humans. Combinations of
drugs may shorten the period of treatment and diminish the collateral toxic effects.