FREE-RADICAL OXIDATION AS A PATHOGENETIC FACTOR OF STOMACH AND DUODENAL INJURY IN EARLY POSTOPERATIVE PERIOD AFTER MAXIMALLY PERMISSIBLE LIVER RESECTION

Aim. Assessment of stomach and duodenal injury early after extended hemihepatectomy. Material and Methods. The experiment was performed on 100 white mongrel male rats. 80 of them underwent advanced hemihepatectomy, 20 animals consisted of control group. After 12 hours, 1, 3 and 7 days after surgery stomach and duodenum were histologically analyzed to detect chemiluminescent homogenates. Results. After 12 hours light sum and “fast” flash in the stomach were increased by 2.5 and 1.5 times, respectively, “slow” flash was decreased by 2 times. Growth of all parameters was observed in duodenum. There were significant decrease of “fast” flash and increase of light sum and “slow” flash in homogenates during 3 postoperative days. By the 7th day light sum was increased in stomach and duodenum, besides the duodenum increased “slow” flash. Structural changes were visualized after 12 hours in the form of erosions and ulcers of the stomach and duodenum. In 7 days reparative changes were predominant. Conclusion. In 12 hours after hemihepatectomy rapid activation of free-radical oxidation was observed in stomach and duodenum. Herewith inhibition of antioxidant enzymes have been already showed in stomach. Structural changes in the stomach (ulcers) have already been irreversible by this time. So, this period is critical for acute stomach and duodenal injury.