Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines

OBJECTIVES: In recent years, the use of plants for the prevention and treatment of cancer is gaining more attention due to their diverse range of phytochemical constituents and fewer adverse effects. In this study, four medicinal plant species from the Kars province of Turkey were investigated for their cytotoxic potential against six different cancer cell lines and one normal cell line. MATERIALS AND METHODS: MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide] assay was performed to assess cytotoxic activity and apoptotic effect was determined using flow cytometry and caspase-3 analyses. RESULTS: ranged between 10% and 30%. CONCLUSION: seed extract have potential for development as therapeutic agents for cytotoxicity on certain cancer cells following further investigation.