Hiroaki Tsuji, Hisashi Yamamoto
Abstract
We have found that a boronic acid catalyzed amidation of an N-hydroxy amino acid methyl ester with amino acid tert-butyl esters gave N-hydroxy dipeptide derivatives in good yields without any racemization. The protecting groups on the nitrogen atom could be easily removed by heterogeneous hydrogenation conditions.
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We have found that a boronic acid catalyzed amidation of an N-hydroxy amino acid methyl ester with amino acid tert-butyl esters gave N-hydroxy dipeptide derivatives in good yields without any racemization. The protecting groups on the nitrogen atom could be easily removed by heterogeneous hydrogenation conditions.
Key concepts: Chemistry, Racemization, Dipeptide, Boronic acid, Catalysis, Nitrogen atom, Amino acid, Organic chemistry