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Bombyx Prothoracicotropic Hormone

Hiroshi Kataoka, Hiromichi Nagasawa, Atsushi Kawakami, Tadanori Oka, Akira Mizoguchi, Masafumi Iwami, Hironori Ishizaki, Akinori Suzuki

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Abstract

Prothoracicotropic hormone ( Bombyx PTTH) of the silkworm, Bombyx mori, was extracted from adult heads. Bombyx PTTH is suggested to be a glycopeptide and consists of two essentially identical subunits. Amino acid sequencing and cDNA analysis revealed the whole amino acid sequence of the subunit, composed of 104-109 residues. Bombyx PTTH stimulated adult development in brainless Bombyx pupae at a dose of ca. 0.1 ng and also enhanced the release of ecdysone in vitro at a concentration of 10 -11 M. Immunohistochemistry and in situ hybridization showed that Bombyx PTTH was transcribed and translated in two pairs of dorso-lateral neurosecretory cells in the brain.

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What this paper is about

Prothoracicotropic hormone ( Bombyx PTTH) of the silkworm, Bombyx mori, was extracted from adult heads. Bombyx PTTH is suggested to be a glycopeptide and consists of two essentially identical subunits. Amino acid sequencing and cDNA analysis revealed the whole amino acid sequence of the subunit, composed of 104-109 residues. Bombyx PTTH stimulated adult development in brainless Bombyx pupae at a dose of ca. 0.1 ng and also enhanced the release of ecdysone in vitro at a concentration of 10 -11 M. Immunohistochemistry and in situ hybridization showed that Bombyx PTTH was transcribed and translated in two pairs of dorso-lateral neurosecretory cells in the brain.

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Available abstract

Prothoracicotropic hormone ( Bombyx PTTH) of the silkworm, Bombyx mori, was extracted from adult heads. Bombyx PTTH is suggested to be a glycopeptide and consists of two essentially identical subunits. Amino acid sequencing and cDNA analysis revealed the whole amino acid sequence of the subunit, composed of 104-109 residues. Bombyx PTTH stimulated adult development in brainless Bombyx pupae at a dose of ca. 0.1 ng and also enhanced the release of ecdysone in vitro at a concentration of 10 -11 M. Immunohistochemistry and in situ hybridization showed that Bombyx PTTH was transcribed and translated in two pairs of dorso-lateral neurosecretory cells in the brain.

Key concepts: Bombyx mori, Bombyx, Bombycidae, Complementary DNA, Biology, Ecdysone, Molecular biology, Protein subunit

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