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2017•Journal of applied science and environmental managementOpen access

Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of Citrus sinensis peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats

P.O. Osarumwense

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Abstract

Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.

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Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.

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Available abstract

Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.

Key concepts: Carrageenan, Chemistry, Traditional medicine, Positive control, Citrus × sinensis, Pharmacology, Anti-inflammatory, Biochemistry

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Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of Citrus sinensis peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats — Research Paper | ScholarLens