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2017•JAMA OphthalmologyOpen access

Evolution of Practice Patterns for the Treatment of Fungal Keratitis

Catherine E. Oldenburg, N. Venkatesh Prajna, Abdou Amza, Allison R. Loh, Nisha R. Acharya, Mark J. Mannis, Thomas M. Lietman

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Abstract

The Mycotic Ulcer Treatment Trial I (MUTT I) demonstrated the superiority of natamycin compared to voriconazole for the treatment of filamentous fungal keratitis.1 This and other recent trials2,3 suggest that natamycin should be the treatment of choice for filamentous fungal keratitis. A survey of experts (~800 surveyed; N=92 respondents) conducted in 2007 found that a majority of clinicians identified voriconazole as their preferred treatment.4 Here, we present results of a repeat survey with identical questions conducted to understand changes in practice patterns for fungal keratitis.

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What this paper is about

The Mycotic Ulcer Treatment Trial I (MUTT I) demonstrated the superiority of natamycin compared to voriconazole for the treatment of filamentous fungal keratitis.1 This and other recent trials2,3 suggest that natamycin should be the treatment of choice for filamentous fungal keratitis. A survey of experts (~800 surveyed; N=92 respondents) conducted in 2007 found that a majority of clinicians identified voriconazole as their preferred treatment.4 Here, we present results of a repeat survey with identical questions conducted to understand changes in practice patterns for fungal keratitis.

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Available abstract

The Mycotic Ulcer Treatment Trial I (MUTT I) demonstrated the superiority of natamycin compared to voriconazole for the treatment of filamentous fungal keratitis.1 This and other recent trials2,3 suggest that natamycin should be the treatment of choice for filamentous fungal keratitis. A survey of experts (~800 surveyed; N=92 respondents) conducted in 2007 found that a majority of clinicians identified voriconazole as their preferred treatment.4 Here, we present results of a repeat survey with identical questions conducted to understand changes in practice patterns for fungal keratitis.

Key concepts: Natamycin, Fungal keratitis, Voriconazole, Medicine, Dermatology, Keratitis, corneal ulcer, Microbiology

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