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2017•Japanese Journal of Oral Diagnosis / Oral MedicineOpen access

A Clinical Research on Prognoses of the Medication-relatedOsteonecroses of the Jaw （MRONJ）

Taiki Suzuki, Yuji Hamada, Miho Takahashi, Kazunari Karakida, Haruo Sakamoto

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Abstract

We conducted a clinical research on the prognoses of 42 patients who were treated for medication-related osteonecrosis of the jaw （MRONJ） in our department, over an 8-year period from November 2008 to May 2016, and obtained the following results. Statistical analysis showed significant differences between the groups of cancer treatment and dosage career of injections.Furthermore, the surgical treatment group showed improvements in symptoms in 80％ of the cases, while the conservative treatment group showed improvements in symptoms in 32％ of the cases. This research suggests the validity of the surgical approach for treating MRONJ.

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What this paper is about

We conducted a clinical research on the prognoses of 42 patients who were treated for medication-related osteonecrosis of the jaw （MRONJ） in our department, over an 8-year period from November 2008 to May 2016, and obtained the following results. Statistical analysis showed significant differences between the groups of cancer treatment and dosage career of injections.Furthermore, the surgical treatment group showed improvements in symptoms in 80％ of the cases, while the conservative treatment group showed improvements in symptoms in 32％ of the cases. This research suggests the validity of the surgical approach for treating MRONJ.

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Available abstract

We conducted a clinical research on the prognoses of 42 patients who were treated for medication-related osteonecrosis of the jaw （MRONJ） in our department, over an 8-year period from November 2008 to May 2016, and obtained the following results. Statistical analysis showed significant differences between the groups of cancer treatment and dosage career of injections.Furthermore, the surgical treatment group showed improvements in symptoms in 80％ of the cases, while the conservative treatment group showed improvements in symptoms in 32％ of the cases. This research suggests the validity of the surgical approach for treating MRONJ.

Key concepts: Osteonecrosis of the jaw, Medicine, Conservative treatment, Statistical analysis, Surgery, Dentistry, Bisphosphonate, Internal medicine

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