2017•Journal of Thoracic DiseaseOpen access

Prophylactic cranial irradiation or no prophylactic cranial irradiation in metastatic small cell lung cancer: is it a relevant question once again?

Cecile Le Pechoux, Angela Botticella, Antonin Lévy, Anne Aupérin

Abstract

Even if chemotherapy is the cornerstone treatment of small cell lung cancer (SCLC), this disease has a particular propensity to recur locally and disseminate in the brain. Hence, there have been several randomized trials assessing the role of thoracic and brain radiotherapy (1). Two individual patient data-based meta-analyses showed that thoracic radiotherapy and prophylactic cranial irradiation (PCI) should be part of the therapeutic strategy (2,3).

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Key concepts: Prophylactic cranial irradiation, Medicine, Conventional PCI, Radiation therapy, Lung cancer, Chemotherapy, Oncology, Randomized controlled trial