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Differences in Electrophoretic Migration of Mouse 7S 2a and 7S 2b Globulins

John E. Coe

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Abstract

The 7Sγ2a and 7Sγ2b globulins of mice differ in their electrophoretic migration. The 7Sγ2a globulin was seen to be slower electrophoretically than 7Sγ2b globulin in the four inbred strains of mice examined and 7Sγ2a globulin free of 7Sγ2b globulin could be obtained by Pevikon-block electrophoresis. Antiserums prepared in rabbits and sheep by inoculation with whole mouse serum frequently contain antibody specific for the 7Sγ2a and 7Sγ2b globulins as well as the 7Sγ1 globulin, and these specificities can be detected on routine immunoelectrophoresis.

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What this paper is about

The 7Sγ2a and 7Sγ2b globulins of mice differ in their electrophoretic migration. The 7Sγ2a globulin was seen to be slower electrophoretically than 7Sγ2b globulin in the four inbred strains of mice examined and 7Sγ2a globulin free of 7Sγ2b globulin could be obtained by Pevikon-block electrophoresis. Antiserums prepared in rabbits and sheep by inoculation with whole mouse serum frequently contain antibody specific for the 7Sγ2a and 7Sγ2b globulins as well as the 7Sγ1 globulin, and these specificities can be detected on routine immunoelectrophoresis.

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Available abstract

The 7Sγ2a and 7Sγ2b globulins of mice differ in their electrophoretic migration. The 7Sγ2a globulin was seen to be slower electrophoretically than 7Sγ2b globulin in the four inbred strains of mice examined and 7Sγ2a globulin free of 7Sγ2b globulin could be obtained by Pevikon-block electrophoresis. Antiserums prepared in rabbits and sheep by inoculation with whole mouse serum frequently contain antibody specific for the 7Sγ2a and 7Sγ2b globulins as well as the 7Sγ1 globulin, and these specificities can be detected on routine immunoelectrophoresis.

Key concepts: Immunoelectrophoresis, Globulin, Gamma globulin, Electrophoresis, Antibody, Alpha globulin, Beta globulins, Chemistry

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