P622Comparison for aspirin plus statin versus statin alone on clinical outcomes during 5-year follow-up period in patient with mild to moderate coronary artery disease

Background: It is well known that the statin has the benefit on prevention of adverse cardiovascular events in patient with mild to moderate coronary artery disease (CAD). However, it is controversial that the addition of aspirin to statin gives better effectivenss over statin alone in long-term clinical outcomes. Methods: A total of 848 consecutive patients with mild to moderate CAD were enrolled for this study. The mild to moderate CAD was define as 30% to 70% stenosis on visual estimate by coronary angiography (CAG). The study group was classified into aspirin plus statin and statin alone. The aspirin plus statin group (n=199) and the statin alone group (n=284). To adjust potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Results: After PSM, baseline characteristics of both groups were balanced. After PSM analysis, 2 propensity-matched groups (131 pairs, n=262) were generated. In clinical outcomes up to 5-year, statin plus aspirin were similar to statin alone in terms of incidence of individual hard endpoints including mortality, myocardial infarction, revascularization and recurrent angina requiring repeat CAG. Aspirin did not reduced to adverse clinical outcomes in patients with insignificant CAD and received statin [Table].