P4408Coronary artery disease in asymptomatic obese patients with erectile dysfunction

Introduction/Purpose: Erectile dysfunction is known from numerous previous studies to be an early indication of coronary artery disease (CAD), while obesity (BMI>30 kg/m2) increases the risk of erectile dysfunction. The purpose of this study is to determine the prevalence of coronary artery disease in asymptomatic obese patients suffering from erectile dysfunction Methods: 205 asymptomatic patients with erectile dysfunction and body mass index (BMI)>30 kg /m2 were evaluated according to their medical history, the International Index of Erectile Function (IIEF), biochemical tests and stress imaging tests (SPECT). Patients with stress imaging test positive for ischemia were subsequently subjected to coronary angiography, in order to establish the diagnosis of coronary artery disease. Results: 47 obese patients with erectile dysfunction and SPECT positive for ischemia were subjected to coronary angiography. 26 of these patients presented with multivessel disease, 19 had one-vessel disease and 2 presented with coronary artery ectasia. Patients with coronary artery disease had significantly higher fasting glucose (p<0,01), CRP (2.2 vs 1.1, p<0,05), LDL (167 vs 136 mg/dl, p<0,05) and uric acid (8,3 vs 6,9 mg/dl, p<0,05) levels, as well as lower HDL levels (33 vs 39 mg/dl, p<0,05) compared to patients without CAD. In addition, patients with CAD had more severe erectile dysfunction for a longer period of time (SHIM score 10,3 vs 15,7 and 32 vs 25 months respectively, p<0,05)