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Preventing Myocardial Injury in Doxorubicin-Treated Children

Harlan M. Krumholz, Sm

Abstract

Doxorubicin, an effective anthracycline therapy for children with acute lymphoblastic leukemia (ALL), can cause myocardial injury, possibly when anthracycline-iron complexes generate free radicals. Dexrazoxane, a free-radical scavenger that effectively protects adults from anthracycline cardiotoxicity, was evaluated in a partially industry-supported trial in children being treated for high-risk, newly …

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Key concepts: Dexrazoxane, Anthracycline, Doxorubicin, Medicine, Cardiotoxicity, Free radical scavenger, Scavenger, Internal medicine