2017•Circulation JournalOpen access
Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases
Fumi Sato, Norikazu Maeda, Takayuki Yamada, Hideyuki Namazui, Shiro Fukuda, Tomoaki Natsukawa, Hirofumi Nagao, Jun Murai, Shigeki Masuda, Yoshimitsu Tanaka, Yoshinari Obata, Yuya Fujishima, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura
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Abstract
BACKGROUND: Excess of visceral fat is a central factor in the pathogenesis of metabolic syndrome (MetS) and atherosclerosis. However, little is known about how much epicardial fat affects cardiometabolic disorders in comparison with visceral or subcutaneous fat. METHODS AND RESULTS: ). Among the low VFA groups, the numbers of subjects with diabetes and coronary atherosclerosis were increased in high EFV group. Among the low EFV groups, the numbers of subjects with diabetes, hyperuricemia, and coronary atherosclerosis were increased among the high VFA subjects. In an age-, sex-, and body mass index (BMI)-adjusted model, EFV was associated with dyslipidemia and MetS, and VFA was significantly associated with hypertension, dyslipidemia, MetS, and coronary atherosclerosis, while SFA was not related with coronary risks and atherosclerosis. CONCLUSIONS: Epicardial fat accumulation may be a risk for coronary atherosclerosis in subjects without visceral fat accumulation. Visceral fat is the strongest risk for cardiometabolic diseases among the 3 types of fat depot.
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