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Measurement of ADP:O values in rat liver homogenates. II. Effects of purine and pyrimidine nucleotides on respiration and phosphorylation.

Eliza Strickland

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Abstract

The effects of a number of nucleotides on respiration and phosphorylation were studied. In all cases where phosphorylation was stimulated, respiration increased correspondingly. Studies with C14-labeled nucleotides gave no indication that non-phosphorylative side reactions interfere with ADP:O measurements. These findings provide additional evidence that ADP:O values are a reliable measure of oxidative phosphorylation in liver homogenates from normal rats.

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The effects of a number of nucleotides on respiration and phosphorylation were studied. In all cases where phosphorylation was stimulated, respiration increased correspondingly. Studies with C14-labeled nucleotides gave no indication that non-phosphorylative side reactions interfere with ADP:O measurements. These findings provide additional evidence that ADP:O values are a reliable measure of oxidative phosphorylation in liver homogenates from normal rats.

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Available abstract

The effects of a number of nucleotides on respiration and phosphorylation were studied. In all cases where phosphorylation was stimulated, respiration increased correspondingly. Studies with C14-labeled nucleotides gave no indication that non-phosphorylative side reactions interfere with ADP:O measurements. These findings provide additional evidence that ADP:O values are a reliable measure of oxidative phosphorylation in liver homogenates from normal rats.

Key concepts: Nucleotide, Purine, Oxidative phosphorylation, Phosphorylation, Respiration, Biochemistry, Adenine nucleotide, Chemistry

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Measurement of ADP:O values in rat liver homogenates. II. Effects of purine and pyrimidine nucleotides on respiration and phosphorylation. — Research Paper | ScholarLens