2017•PubMedOpen access

The Potential Use of Methotrexate in the Treatment of Cutaneous Leishmaniasis: In Vitro Assays against Sensitive and Meglumine Antimoniate-resistant Strains of Leishmania tropica.

Hossein Mahmoudvand, Farnaz Kheirandish, Seyed Reza Mirbadie, Mohammad Hassan Kayedi, Tahereh Rezaei Riabi, Abbas Ali Ghasemi, Mehdi Bamorovat, Iraj Sharifi

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Abstract

BACKGROUND: stages in vitro. METHODS: are referred to those isolates that are responsive or non-responsive to one or two courses of treatment by MA systemically and/or intralesionally, respectively. RESULTS: 0.05) reduced when it was preincubated with MTX. CONCLUSION: using a clinical setting.

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Available abstract

Key concepts: Leishmania tropica, Meglumine antimoniate, Cutaneous leishmaniasis, Amastigote, Leishmania, IC50, Microbiology, In vitro