The hemodynamic effects of Milrinone in patients with sepsis and low cardiac output

Objective To study the hemodynamic effects of Milrinone in patients with sepsis and low cardiac output. Methods The study was conducted on 13 patients with sepsis and low cardiac output recruited at the surgical intensive care unit(SICU)of Beijing Hospital from March 2011 to June 2012.Continuous IV infusion of Milrinone was made at 0.25-0.50μg·kg-1·min-1.Hemodynamic variables were monitored by PiCCO, and data at baseline, 10 min, 2 h, and 24 h after infusion were analyzed. Results No statistical differences were found between measurements at baseline and 10min after milrinone infusion in variables such as systolic pressure, diastolic pressure, mean arterial pressure(MAP), heart rate, central venous pressure(CVP), global end diastolic volume index(GEDI), cardiac index(CI), cardiac function index CFI), stroke volume index(SVI)and systemic vessel resistance index(SVRI). Increased CI(2.73±0.62, 2.93±0.49 vs.2.33±0.57), CFI(3.59±0.84, 3.85±0.84 vs.3.12±0.93)and SVI(28.62±10.32, 28.77±9.85 vs.25.31±9.09)and decreased SVRI(2 269±615.3, 2 094±542.2 vs.2 946±1 417.0)were observed at 2 h and 24 h after Milrinone infusion, compared with baseline data. Conclusions Continuous IV infusion of low dose milrinone can increase cardiac output and decrease systemic vascular resistance in patients with sepsis and low cardiac output. Key words: Milrinone; Sepsis; output low cardiac; Hemodynamics