ScholarLens Back to search
2017•Obstetrical & Gynecological SurveyRequires access

Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease

John H. Zhang, Hui Liu, Shiyu Luo, Lu Zhuo, Alejandro Chávez-Badiola, Zitao Liu, Mingxue Yang, Zaher O Merhi, Sherman J. Silber, S. Munné, Michalis Konstandinidis, Dagan Wells, Taosheng Huang

Open publisher page 26 citations

Abstract

(Abstracted from Reprod Biomed 2017;34:361–368) It is estimated that at least 1 in 5000 people in the general population has 1 mutation in mitochondrial DNA (mtDNA), which can cause maternally inherited mitochondrial disorders. When both mutant mitochondrial and wild-type (normal) genomes coexist (heteroplasmy), the severity of symptoms is associated with the level of mtDNA mutation load or degree of heteroplasmy.

About this research paper

What this paper is about

(Abstracted from Reprod Biomed 2017;34:361–368) It is estimated that at least 1 in 5000 people in the general population has 1 mutation in mitochondrial DNA (mtDNA), which can cause maternally inherited mitochondrial disorders. When both mutant mitochondrial and wild-type (normal) genomes coexist (heteroplasmy), the severity of symptoms is associated with the level of mtDNA mutation load or degree of heteroplasmy.

Why it matters

OpenAlex reports 26 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

(Abstracted from Reprod Biomed 2017;34:361–368) It is estimated that at least 1 in 5000 people in the general population has 1 mutation in mitochondrial DNA (mtDNA), which can cause maternally inherited mitochondrial disorders. When both mutant mitochondrial and wild-type (normal) genomes coexist (heteroplasmy), the severity of symptoms is associated with the level of mtDNA mutation load or degree of heteroplasmy.

Key concepts: Heteroplasmy, Mitochondrial DNA, Mitochondrial disease, Oocyte, Genetics, Medicine, Mutation, Population

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease — Research Paper | ScholarLens