Effects of oxygen atomizing inhalation ambroxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation in rabbits

Objective To investigate the effects of oxygen atomizing inhalation of low dose ambr- oxol on the inflammatory response to non-ventilatied lung undergoing one lung ventilation （OLV）. Methods Fourty healthy rabbits were randomly divided into control group （ group C） receiving two-lung ventilation for two h, group OLV receiving right-lung ventilation for 2 h, group intravenous administration of ambroxol （IA） receiving intraveous injection of ambroxol 15 mg/kg, and group oxygen drive atomization inhalation of ambroxol （AIA） receiving oxygen atomizing inhalation of ambroxol 7.5 mg before right-lung ventilation for 2 h. The concentrations of tumor necrosis factor （TNF）-a, interleukin （IL）-113, IL-8, and IL-10 in left tracheal fluid were determined. Results TNF-oL, IL-113 and IL-8 concentrations in left tracheal fluid were （69. 88±18. 54）, （61.54 ± 10. 92 ）, and （49. 53 ± 8.28 ） ng/L respectively, which were significantly increased in group AIA as compared with those in group OLV [（ 16.04 ± 1.41 ）, （ 3.46±0. 27 ）, and （ 16. 87 -± 1.73） ng/L] , while IL-10 concentration was （ 12. 60 ± 0. 98 ） ng/L, which was significantly higher in group AIA than in group OLV [（ 16. 56 ± 1.36） rig/L] （ P 〈 0. O1 ）. Conclusion Oxygen atom- izing inhalation of low dose ambroxol can inhibit the inflammatory response to non-ventilatied lung undergo- ing OLV in rabbits. Key words: Ambroxol;  Respiratory, artificial;  Inflammation;  Rabbit