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2016•Unpublished venueRequires access

Hepatitis C virus control: viral resistance, new therapeutic targets and host defense

Gaber Moawad, Hanaa Abdalla Mohamed

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Abstract

Hepatitis C virus (HCV) has chronically infected infects more than 170 million humans, making it a mojor health threat. First directly acting antivirals were protease inhibitors (Boceprevir and Telaprevir) associated with drug resistance. We studied viral resistance to protease inhibitors, crystallised the HCV non-structural 5b protein as a new target for anti-HCV drug development, and studied the role of several host defence proteins in HCV infection.

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What this paper is about

Hepatitis C virus (HCV) has chronically infected infects more than 170 million humans, making it a mojor health threat. First directly acting antivirals were protease inhibitors (Boceprevir and Telaprevir) associated with drug resistance. We studied viral resistance to protease inhibitors, crystallised the HCV non-structural 5b protein as a new target for anti-HCV drug development, and studied the role of several host defence proteins in HCV infection.

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Available abstract

Hepatitis C virus (HCV) has chronically infected infects more than 170 million humans, making it a mojor health threat. First directly acting antivirals were protease inhibitors (Boceprevir and Telaprevir) associated with drug resistance. We studied viral resistance to protease inhibitors, crystallised the HCV non-structural 5b protein as a new target for anti-HCV drug development, and studied the role of several host defence proteins in HCV infection.

Key concepts: Telaprevir, Boceprevir, Virology, Hepatitis C virus, Protease, Virus, Drug resistance, Hepacivirus

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