COMPARISON OF 0.1% ADAPALENE CREAM WITH 0.1% TAZAROTENE CREAM IN THE TREATMENT OF ACNE VULGARIS

BACKGROUND \nAcne vulgaris is a self-limiting disorder of the pilosebaceous unit that is seen primarily in adolescents. Acne therapy aims at \nreduction of sebum production, correcting the abnormal ductal keratinisation, reducing the colony of propionic bacterium \nacnes and preventing the release of inflammatory mediators that are basically responsible for the pathogenesis of acne. \nMATERIALS AND METHODS \nThe aim of the study was to compare the efficacy of topical adapalene 0.1% cream and topical tazarotene 0.1% cream in the \ntreatment of acne vulgaris. One hundred patients of either sex were enrolled and randomly assigned for the above study. The \nstudy was prospective, randomized, single blinded controlled clinical trial. Inclusion Criteria- Patients of either sex with mild to \nmoderate acne vulgaris. Exclusion Criteria- Pregnant and lactating women, age below 12 years and drug induced Acneiform \nlesions. Number of comedones, papules and pustules were counted and graded. Clinical photographs of the lesions were \ntaken before commencement of therapy and after completion of therapy. \nRESULTS \nBy this study we evaluated the gender and age prevalence, precipitating factors for acne and other associated skin conditions \nwith acne. Treatment with topical adapalene showed good improvement (80.3%) than with topical 0.1% tazarotene cream \n(54.07%). \nCONCLUSION \nPatients treated with 0.1% adapalene cream showed excellent response and patients treated with 0.1% tazarotene showed \nincreased side effects and reduced tolerance.