Detection of myocardial perfusion defect with 320-row volume CT myocardial perfusion imaging

Objective To evaluate the feasibility of 320-row volume CT myocardial perfusion imaging (CT-MPI) in detecting myocardial perfusion defect.Methods Fourteen patients with positive single-positron emission computed tomography myocardial perfusion imaging (SPECT-MPI) findings underwent both rest and adenosine stress 320-row volume CT-MPI.Rest and stress CT perfusion images were analyzed by employing dedicated software in 320-row CT workstation.Both SPECT-MPI and CT-MPI were evaluated for fixed and reversible perfusion defects using a 16-segment model (apex was excluded).The sensitivity,specificity of 320-row volume CT-MPI in detecting myocardial perfusion defect were evaluated by taking SPECT-MPI as a reference standard.Results Both rest and stress 320-row volume CT-MPI were successfully performed in all patients.Thirty nine segments with fixed or reversible perfusion defects in all patients were depicted by SPECT-MPI,while 34 perfusion defects in 12 patients were identified by CT-MPI.The sensitivity,specificity of 320-row volume CT-MPI for detection of perfusion defects were 87.2％(34/39),91.4％ ( 169/185 ),respectively.Conclusion 320-row volume CT-MPI has high sensitivity and specificity for detection of myocardial perfusion defects. Key words: Coronary disease;  Tomography, X-ray computed;  Myocardium;  Perfusion