2017•PubMedRequires access

[The study of using salvianolate treat acute lung injury in rats induced by paraquat].

Z W Wang, X X Li, Xi Jian, Z C Zhang, Baotian Kan

Abstract

Paraquat (50 mg/kg body weight) to fill the stomach can be induced model of acute lung injury in the rats. The serum HO-1 expression and HO-1, HYP content in lung tissue increased obviously in model rats. Salvia miltiorrhiza polyphenols acid salt to a certain degree and stage influenced the expression of HO-1 and HYP, relieve acute lung injury and pulmonary fibrosis, has certain curative effect in the treatment of paraquat poisoning.

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Available abstract

Key concepts: Paraquat, Saline, Lung, Hydroxyproline, Medicine, Salvia miltiorrhiza, Intraperitoneal injection, Therapeutic effect