Effect of granulocyte colony stimulating factor on cytokines in rabbits with myocardial infarction

Objective To find out the changes in blood cell counts and inflammatory cytokines after granulocyte colony stimulating factor (G-CSF) traetment in rats with myocardial infarction.Methods Thirty-eight healthy New Zealand white rabbits were divided into two groups:10 μg/(kg· day) G-CSF in G-CSF group and 0.5 ml/(kg·d) saline in control group starting at 24th h after infarction,once daily for 5 days.Results White blood cells (WBC) and granulocytes (N) were significantly increased in G-CSF group as compared with those in control group (P ＜ 0.05) at 7th and 14th day after myocardial infarction.High sensitivity C reactive protein (HsCRP) levels in G-CSF and control group were (7.32 ±2.32) mg/L and (6.53 ± 1.21) mg/L at 7th day (P ＞0.05),and (2.02 ± 1.57) mg/L and (4.12 ±0.68) mg/L at 14th day after myocardial infarction (P ＜0.05),respectively.TNF-α levels in G-CSF and control groups were (80.1 ±40.1) ng/L and (74.4±39.1) ng/L at 7th day (P＞0.05),and (40.9±17.7) ng/L and (53.2 ± 14.8) ng/L at 14th day after myocardial infarction (P ＜ 0.05),respectively.Conclusion G-CSF can increase the number of white blood cell(WBC) and restore inflamation cytokine early. Key words: Myocardial infarction;  Cytokine;  Granulocyte colony stimulating factor