2001•Journal of the Korean Wood Science and TechnologyRequires access

Studies on Biological Activity of Wood Extractives(VII) - Antifungal activity of Isoflavonoids from Sophora japonica -

Youngki Park, Hak‐Ju Lee, Sung-Suk Lee, Don‐Ha Choi, Woon‐Hong Yeo, Jung‐Soo Oh

Abstract

Three isoflavones and one isoflavanone were isolated from the wood of Sophora japonica (Leguminosae) which has been selected due to its high antifungal activity among the tested species, Four compounds were identified as 5,7-dihydroxy-4',6-dimethoxyisoflavone (irisolidone), 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A), 7-hydroxy-4'-methoxyisoflavone (formononetin) and 7-hydroxy-4'-methoxy-isoflavanone by Mass and NMR spectroscopic analysis. The antifungal activity of the isoflavonoids was tested by medium dilution method and showed low antifungal activity indicating that the other compounds may contribute to high activity of the wood extractives of S. japonica.

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Key concepts: Formononetin, Antifungal, Isoflavones, Chemistry, Biochanin A, Traditional medicine, Food science, Biochemistry