2012•Zhonghua neifenmi daixie zazhiRequires access

The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet

Huiqiang Liu, Lina Pei, Du Jian, Jing Yang, Zhang Ying-yan

Abstract

High-fat diet-induced insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique.Compared with the control group,the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet( P＜0.05 ),which was increased by metformin( P＜0.05 ).These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression. Key words: Insulin resistance; Vaspin; Metformin; Euglycemic-hyperinsulinemic clamp; Rats

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Internal medicine, Endocrinology, Metformin, Insulin resistance, Adipose tissue, Insulin, Glucose clamp technique, Messenger RNA