522 Image-based analysis of cancellous bone reflecting micro-structure inside of trabecula

Osteocytes embedded in bone matrix are recognized as the mechanosensor cells that play important roles in adaptive bone remodeling. Therefore, mechanical condition of bone matrix around osteocytes is a key factor to understand the mechanism of adaptive bone remodeling. In this study, finite element models of cancellous bone at tissue level considering trabecular network and that at trabecular microstructure level, containing lacuno/canalicula, were constructed by the image-based modeling method. Trabecular internal structure, the micro-scale structure, was homogenized, and substituted into cancellous bone, the macro-structure. Mechanical analysis at macro-scale and localization indicated the mechanical condition of micro-scale trabecular structure for tissue level load.