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2017•PubMedOpen access

Pro- and antiangiogenic VEGF and its receptor status for the severity of diabetic retinopathy.

Suman Kalyan Paine, Lakshmi Kanta Mondal, Prasanta Kumar Borah, Chandra Bhattacharya, Jagadish Mahanta

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Abstract

PURPOSE: b) VEGF isoforms and its soluble receptors for severity of DR. METHODS: b (antiangiogenic), VEGF receptor 1 (VEGFR1), VEGFR2, and VEGFR3 in plasma were determined with enzyme-linked immunosorbent assay (ELISA). RESULTS: a-b concomitantly increased statistically significantly with the severity of the disease (p<0.0001), patients with diffuse diabetic macular edema (DME) with proliferative DR (PDR) had the highest imbalance. The plasma soluble form of VEGFR2 concentration consistently increased statistically significantly with the severity of the disease (p<0.0001). CONCLUSIONS: b) homeostasis of the VEGF isoforms, seems crucial for an adverse prognosis of DR and may be a better explanatory marker compared with either VEGF isoform.

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PURPOSE: b) VEGF isoforms and its soluble receptors for severity of DR. METHODS: b (antiangiogenic), VEGF receptor 1 (VEGFR1), VEGFR2, and VEGFR3 in plasma were determined with enzyme-linked immunosorbent assay (ELISA). RESULTS: a-b concomitantly increased statistically significantly with the severity of the disease (p<0.0001), patients with diffuse diabetic macular edema (DME) with proliferative DR (PDR) had the highest imbalance. The plasma soluble form of VEGFR2 concentration consistently increased statistically significantly with the severity of the disease (p<0.0001). CONCLUSIONS: b) homeostasis of the VEGF isoforms, seems crucial for an adverse prognosis of DR and may be a better explanatory marker compared with either VEGF isoform.

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Available abstract

PURPOSE: b) VEGF isoforms and its soluble receptors for severity of DR. METHODS: b (antiangiogenic), VEGF receptor 1 (VEGFR1), VEGFR2, and VEGFR3 in plasma were determined with enzyme-linked immunosorbent assay (ELISA). RESULTS: a-b concomitantly increased statistically significantly with the severity of the disease (p<0.0001), patients with diffuse diabetic macular edema (DME) with proliferative DR (PDR) had the highest imbalance. The plasma soluble form of VEGFR2 concentration consistently increased statistically significantly with the severity of the disease (p<0.0001). CONCLUSIONS: b) homeostasis of the VEGF isoforms, seems crucial for an adverse prognosis of DR and may be a better explanatory marker compared with either VEGF isoform.

Key concepts: Diabetic retinopathy, Medicine, Internal medicine, Endocrinology, Homeostasis, Vascular endothelial growth factor, Concomitant, Retinopathy

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Pro- and antiangiogenic VEGF and its receptor status for the severity of diabetic retinopathy. — Research Paper | ScholarLens