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2016•Unpublished venueRequires access

Effects of edaravone on synaptic plasticity in hippocampus neurons of vascular dementia rat

Dandan Liu

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Abstract

Objective: To investigate the effect of edaravone (Eda) on synaptic plasticity in hippocampus neurons of vascular dementia (VD) rat, and explore the molecular mechanisms. Methods: Thirty male Sprague-Dawley rats were randomly divided into 3 groups, which were sham group (n=10), VD group (n=10) and VD + Eda group (n=10). The spatial cognition was measured by Morris water maze (MWM) test. The long-term potentiation (LTP) in hippocampal CA1 area was recorded and further compared after MWM. After the electrophysiological experiment, all rats were killed and their brains were isolated respectively. The expression of growth associated protein (GAP- 43) in CA1 area of each rat was analyzed by immunohistochemical staining. Results: VD rats showed significant

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Objective: To investigate the effect of edaravone (Eda) on synaptic plasticity in hippocampus neurons of vascular dementia (VD) rat, and explore the molecular mechanisms. Methods: Thirty male Sprague-Dawley rats were randomly divided into 3 groups, which were sham group (n=10), VD group (n=10) and VD + Eda group (n=10). The spatial cognition was measured by Morris water maze (MWM) test. The long-term potentiation (LTP) in hippocampal CA1 area was recorded and further compared after MWM. After the electrophysiological experiment, all rats were killed and their brains were isolated respectively. The expression of growth associated protein (GAP- 43) in CA1 area of each rat was analyzed by immunohistochemical staining. Results: VD rats showed significant

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Available abstract

Objective: To investigate the effect of edaravone (Eda) on synaptic plasticity in hippocampus neurons of vascular dementia (VD) rat, and explore the molecular mechanisms. Methods: Thirty male Sprague-Dawley rats were randomly divided into 3 groups, which were sham group (n=10), VD group (n=10) and VD + Eda group (n=10). The spatial cognition was measured by Morris water maze (MWM) test. The long-term potentiation (LTP) in hippocampal CA1 area was recorded and further compared after MWM. After the electrophysiological experiment, all rats were killed and their brains were isolated respectively. The expression of growth associated protein (GAP- 43) in CA1 area of each rat was analyzed by immunohistochemical staining. Results: VD rats showed significant

Key concepts: Long-term potentiation, Hippocampus, Morris water navigation task, Synaptic plasticity, Vascular dementia, Hippocampal formation, Edaravone, Neuroscience

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