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2017•Complex Issues of Cardiovascular DiseasesOpen access

SURFACE MODIFICATION OF BARE-METAL STENTS FOR PREVENTING RESTENOSIS (PART 1)

А. И. Лотков, Larisa V. Antonova, Oleg A. Kashin, В. Г. Матвеева, A. N. Kudryashov

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Abstract

The therapeutic e[cacy of bare-metal stents is signiVcantly limited due to frequent restenosis. Here we review the approaches for surface modiVcation to prevent restenosis, presented the advantages and disadvantages of each method. In the Vrst part of the review, we consider antithrombotic and antiproliferative stents coating. The review presents the most signiVcant and interesting research aimed forming endothelial layer on the stents surface in vitro.

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The therapeutic e[cacy of bare-metal stents is signiVcantly limited due to frequent restenosis. Here we review the approaches for surface modiVcation to prevent restenosis, presented the advantages and disadvantages of each method. In the Vrst part of the review, we consider antithrombotic and antiproliferative stents coating. The review presents the most signiVcant and interesting research aimed forming endothelial layer on the stents surface in vitro.

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Available abstract

The therapeutic e[cacy of bare-metal stents is signiVcantly limited due to frequent restenosis. Here we review the approaches for surface modiVcation to prevent restenosis, presented the advantages and disadvantages of each method. In the Vrst part of the review, we consider antithrombotic and antiproliferative stents coating. The review presents the most signiVcant and interesting research aimed forming endothelial layer on the stents surface in vitro.

Key concepts: Restenosis, Bare metal, Antithrombotic, Coating, Medicine, Surface modification, Materials science, Stent

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