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2017•European Journal of Organic ChemistryRequires access

A Facile One‐Pot Synthesis of 1,2,3‐Tri‐ and 1,1,2,3‐Tetrasubstituted Bis(guanidine)s from Bis(thiourea)s

Valentin Vass, Maximilian Dehmel, Florian Lehni, Robert Kretschmer

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Abstract

A facile and efficient one‐pot strategy for the preparation of 1,2,3‐tri‐ and 1,1,2,3‐tetrasubstituted bis(guanidine)s by starting from from readily available bis(thiourea)s has been successfully developed. The reaction provides products that contain a range of terminal and bridging groups. After a simple workup procedure, the products were obtained in analytically pure and in good to excellent yields.

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What this paper is about

A facile and efficient one‐pot strategy for the preparation of 1,2,3‐tri‐ and 1,1,2,3‐tetrasubstituted bis(guanidine)s by starting from from readily available bis(thiourea)s has been successfully developed. The reaction provides products that contain a range of terminal and bridging groups. After a simple workup procedure, the products were obtained in analytically pure and in good to excellent yields.

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OpenAlex reports 13 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A facile and efficient one‐pot strategy for the preparation of 1,2,3‐tri‐ and 1,1,2,3‐tetrasubstituted bis(guanidine)s by starting from from readily available bis(thiourea)s has been successfully developed. The reaction provides products that contain a range of terminal and bridging groups. After a simple workup procedure, the products were obtained in analytically pure and in good to excellent yields.

Key concepts: Chemistry, Guanidine, Thiourea, Combinatorial chemistry, Organic chemistry, Medicinal chemistry

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A Facile One‐Pot Synthesis of 1,2,3‐Tri‐ and 1,1,2,3‐Tetrasubstituted Bis(guanidine)s from Bis(thiourea)s — Research Paper | ScholarLens