Acute Liver Failure Secondary to AL Amyloidosis

AL amyloidosis, the most common form of amyloidosis, involves the extracellular deposition of immunoglobulin light chain protein fibrils, usually in the setting of a plasma cell dyscrasia. Amyloid deposition can occur in any organ system, including the gastrointestinal tract and liver. In autopsy studies, liver involvement in AL amyloidosis is common but usually has minimal and nonspecific clinical manifestations. Acute liver failure from AL amyloidosis is rare and has only been noted in a few individual case reports. Here, we report a case of AL amyloidosis, likely due to a plasma cell dyscrasia, presenting as rapid development of acute liver failure.