Comparing the Injection Pain of Propofol Emulsion 1% (MCT/LCT) and Propofol Emulsion 2% (Propofol Lipuro) in Combination with Lidocaine in Patients Undergoing Gynecologic Surgery with General Anesthesia

Background: Propofol causes a high incidence of pain during intravenous injection. The aim of this study was to compare incidence and severity of injection pain following the administration of two different formulations of Propofol with and without 10mg Lidocaine in female patients. Methods: One hundred ASA (American Society of Anesthesiologists) grade I and II patients, planned to undergo gynecologic surgery under general anesthesia, were included in four groups of 25 in a prospectively, randomized and double-blind study. Group A received Propofol 1%+10mg lidocaine (1cc of lidocaine1%), Group B received Propofol 1%+ 1cc preservative-free saline, Group C received Lipuropropofol +10mg lidocaine (1cc of lidocaine1%) and Group D received Lipuropropofol+1cc preservative-free saline. Injection pain was assessed using the McCrirrick and Hunter scale. Results: No differences were found in the mean age, weight and given dose of propofol administered between all groups (P>0.05). Comparison of groups revealed significant difference in pain scores between groups (mean pain scores, GroupA:2.84 ± 0.850 vs. GroupB:3.16 ± 0.800 vs. GroupC:1.8±0.866 vs. GroupD:2.12±0.833 points). Conclusion: The highest pain scores were found in the propofol1% without lidocaine use while lipuropropofol plus lidocaine had the lowest pain scores. We recommend premixing 10 mg of lidocaine to Lipuropropofolfor preventing or mitigation of propofol injection pain compared to Lipuropropofol alone or propofol1% with lidocaine.