Kriteriji povećanja bioreaktora

Differences between transport and kinetics phenomena in different bioreactor volumes are related to the bioreactor scale-up problems. These phenomena together with differences between great number of specific bioprocesses are the main reasons for the fact that a general scale-up procedure is not established. In this work, the scale-up problems of bioreactor with pseudohomogeneous bioprocess (homogeneous distribution of microorganisms and suspended particles in medium) were considered. The criteria for the scale-up of bioreactor with pseudohomogeneous bioprocess and their relations to the bioprocess and system parameters were studied. Industrial bioprocesses are mainly characterised by heterogeneous distribution of system components. Aerobic bioprocesses are the most numerous group of heterogeneous bioprocesses. In this work, criteria for the scale up of different bioreactor types with heterogeneous bioprocesses were studied in details. Besides the geometrical and hydrodynamic similarity for successful scale-up of bioreactor it is necessary to obtain the physiological similarity of the bioprocess in laboratory and industrial scale. Therefore, the bioprocesses with flocs, pellets and microbial biofilm were also studied. For these bioprocesses, mathematical relations between bioprocess and system parameters were also presented. For mathematical description of phenomena in heterogeneous systems structured models are most often used. These models are characterised by mass or heat balances equations that usually define relations between bioprocess and bioreactor parameters. Obtained mathematical models are very often used with other criteria in the scale-up of biorector with heterogeneous systems.