2007•Unpublished venueRequires access
Therapeutic drug monitoring of mycophenolic acid in patients with kidney transplant
Zvonimir Puretić, Paula Granić, Ljubica Bubić-Filipi, Zdenka Lalić, Mila Lovrić, Ines Humar, Željka Mustapić, Jadranka Sertić, Kes P
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Abstract
Mycophenolate mofetil (MMF) is an immunosupressive drug used in prophylaxis of rejection of transplanted solid organs in combination with cyclosporine A (CyA) and steroids. It is metabolised in the liver to the active component mycophenolic acid (MPA), an irreversible noncompetitive inhibitor of cell enzime 5'-monophosphate (IMP)dehydrogenase. The aim of the study was...