ScholarLens Back to search
2007•Immunology Endocrine & Metabolic Agents - Medicinal ChemistryRequires access

Adenosine and Inflammation

Bruce N. Cronstein

Open publisher page 2 citations

Abstract

Adenosine is a potent physiologic mediator that is released by cells following such stresses as hypoxia and exposure to reactive oxygen species (ROS). By binding to one or more of four known receptors, A1, A2A, A2B and A3 (all members of the family of G protein coupled receptors), adenosine suppresses inflammation and immunologic reactions. Here we review the expression and functional effects of these receptors on inflammatory cells and discuss the potential use of adenosine receptor agonists or agents that increase local adenosine concentrations in the treatment of inflammatory diseases or promotion of wound healing. Keywords: Adenosine, adenosine receptors, P1 purinoceptors, methotrexate, wound healing, inflammation

About this research paper

What this paper is about

Adenosine is a potent physiologic mediator that is released by cells following such stresses as hypoxia and exposure to reactive oxygen species (ROS). By binding to one or more of four known receptors, A1, A2A, A2B and A3 (all members of the family of G protein coupled receptors), adenosine suppresses inflammation and immunologic reactions. Here we review the expression and functional effects of these receptors on inflammatory cells and discuss the potential use of adenosine receptor agonists or agents that increase local adenosine concentrations in the treatment of inflammatory diseases or promotion of wound healing. Keywords: Adenosine, adenosine receptors, P1 purinoceptors, methotrexate, wound healing, inflammation

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Adenosine is a potent physiologic mediator that is released by cells following such stresses as hypoxia and exposure to reactive oxygen species (ROS). By binding to one or more of four known receptors, A1, A2A, A2B and A3 (all members of the family of G protein coupled receptors), adenosine suppresses inflammation and immunologic reactions. Here we review the expression and functional effects of these receptors on inflammatory cells and discuss the potential use of adenosine receptor agonists or agents that increase local adenosine concentrations in the treatment of inflammatory diseases or promotion of wound healing. Keywords: Adenosine, adenosine receptors, P1 purinoceptors, methotrexate, wound healing, inflammation

Key concepts: Adenosine receptor, Adenosine, Purinergic signalling, Inflammation, Adenosine A3 receptor, Receptor, Adenosine A2B receptor, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Adenosine and Inflammation — Research Paper | ScholarLens