A. K. Ghosh, D. R. Nicponski
Abstract
Significance The authors have developed a mild Cu(OTf) 2 -bisphosphine-catalyzed reaction for the synthesis of substituted tetrahydropyran derivatives. The reaction proceeds via an olefin migration followed by a Prins cyclization to provide a range of tetrahydropyran derivatives in good yields and excellent trans diastereoselectivity.
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Significance The authors have developed a mild Cu(OTf) 2 -bisphosphine-catalyzed reaction for the synthesis of substituted tetrahydropyran derivatives. The reaction proceeds via an olefin migration followed by a Prins cyclization to provide a range of tetrahydropyran derivatives in good yields and excellent trans diastereoselectivity.
Key concepts: Tetrahydropyran, Prins reaction, Chemistry, Catalysis, Olefin fiber, Reaction conditions, Combinatorial chemistry, Organic chemistry