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2011•Der Pharmacia SinicaRequires access

Semicarbazone analogues: A mini review

Mohamed Jawed Ahsana, Jeyabalan Govinda Samy, Habibullah Khalilullah, Md. Shivli Nomani

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Abstract

Semicarbazones are compounds which are synthesized by the condensation of semicarbazide and aldehydes/ketones. The literature survey revealed that semicarbazones had been emerged as a compound with broad range of activities including anticonvulsant, antitubercular, anticancer and antimicrobial activity. Dimmock et al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone as potential anticonvulsant. Preclinical evaluations have been completed and an IND has been filed for this potential compound. In the present study we have focused on the biological activity of semicarbazone analogues.

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What this paper is about

Semicarbazones are compounds which are synthesized by the condensation of semicarbazide and aldehydes/ketones. The literature survey revealed that semicarbazones had been emerged as a compound with broad range of activities including anticonvulsant, antitubercular, anticancer and antimicrobial activity. Dimmock et al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone as potential anticonvulsant. Preclinical evaluations have been completed and an IND has been filed for this potential compound. In the present study we have focused on the biological activity of semicarbazone analogues.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Semicarbazones are compounds which are synthesized by the condensation of semicarbazide and aldehydes/ketones. The literature survey revealed that semicarbazones had been emerged as a compound with broad range of activities including anticonvulsant, antitubercular, anticancer and antimicrobial activity. Dimmock et al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone as potential anticonvulsant. Preclinical evaluations have been completed and an IND has been filed for this potential compound. In the present study we have focused on the biological activity of semicarbazone analogues.

Key concepts: Semicarbazone, Semicarbazide, Chemistry, Benzaldehyde, Antimicrobial, Thiazole, Anticonvulsant, Stereochemistry

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