Remediation of hepatic antioxidant defense system during ethanol withdrawal stress with dietary ginger

This analysis has been conducted to investigate the influence of ginger on hepatic antioxidant enzymes system in rats withdrawan from ethanol treatment. Ethanol withdrawal showed a marked decrease in the superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione content while an increase of malondialdehyde (MDA) levels were estimated in the hepatic tissue. This effect was reversed by treatment with 1% dietary ginger for 4 weeks in rats that showed improved antioxidant status which suggest that treatment of ginger may have protective role against both the ethanol and withdrawal induced hepatotoxicity.