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2017•International Journal of Drug Research and TechnologyRequires access

ANTIFUNGAL RESISTANCE IN CANDIDA SPECIES: AN OVERVIEW

Sachin Chandrakant Deorukhkar, Shahriar Bahman Roushani, Namita A. Raytekar

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Abstract

Over the past few decades, the prevalence of fungal infections has dramatically increased due to the growing number of populations at high risk. Although Candida albicans is considered as the most prevalent species, in recent years non albicans Candida (NAC) spp. are increasingly reported from various clinical types of Candida infections. NAC spp. are either innately resistant to antifungal drugs or may acquire resistance during course of therapy. Antifungal resistance once rarely documented in Candida spp. is now being increasing reported from various parts of world. The development of antifungal drug resistance in Candida spp. with different mechanisms has potential clinical impact. In this review, various aspects of antifungal resistance in Candida spp. are discussed.

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What this paper is about

Over the past few decades, the prevalence of fungal infections has dramatically increased due to the growing number of populations at high risk. Although Candida albicans is considered as the most prevalent species, in recent years non albicans Candida (NAC) spp. are increasingly reported from various clinical types of Candida infections. NAC spp. are either innately resistant to antifungal drugs or may acquire resistance during course of therapy. Antifungal resistance once rarely documented in Candida spp. is now being increasing reported from various parts of world. The development of antifungal drug resistance in Candida spp. with different mechanisms has potential clinical impact. In this review, various aspects of antifungal resistance in Candida spp. are discussed.

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Available abstract

Over the past few decades, the prevalence of fungal infections has dramatically increased due to the growing number of populations at high risk. Although Candida albicans is considered as the most prevalent species, in recent years non albicans Candida (NAC) spp. are increasingly reported from various clinical types of Candida infections. NAC spp. are either innately resistant to antifungal drugs or may acquire resistance during course of therapy. Antifungal resistance once rarely documented in Candida spp. is now being increasing reported from various parts of world. The development of antifungal drug resistance in Candida spp. with different mechanisms has potential clinical impact. In this review, various aspects of antifungal resistance in Candida spp. are discussed.

Key concepts: Candida albicans, Candida infections, Antifungal, Biology, Antifungal drug, Antifungal drugs, Drug resistance, Microbiology

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