2014•Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)Open access
Effects of Ketoprofen Tape Products on Carrageenan Induced Paw Edema
Kazuaki Matsumoto, T. Kohno, Tetsuya Sugiyama, Yasutaka Sakamoto, Ayumi Shimada, Yuko Kuroda, Tomoko Terajima, Kayoko Maezawa, Junko Kizu
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Abstract
Differences in the anti-inflammatory effects induced by brand-name and generic ketoprofen tapes have not yet been examined. The aim of the present study was to investigate the anti-inflammatory effects of 9 ketoprofen tapes on rat carrageenan-induced paw edema and also determine the amount of ketoprofen released from these tapes. The suppression of carrageenan-induced paw edema more than 3 hours after the tapes had been applied was significantly stronger with the 4 ketoprofen tapes tested than with the control. The brand-name product released the highest amount of ketoprofen 3 hours after the tapes had been applied. The amount of ketoprofen released from the brand-name product was higher than that by 4 out of the 8 generic products tested. Furthermore, a correlation was found between anti-inflammatory effects and the amount of ketoprofen released 3 hours after applying the ketoprofen tapes (r = 0.552). Thus, the biological equivalents of generic products should be considered because the anti-inflammatory effects and amount of ketoprofen released differed between the brand-name and generic ketoprofen tapes.
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