813 Visualization of Thrombus Formation on Shear Flow(2)

This paper describes the visualization of thrombus formation process by using the plasma water to develop the CFD based prediction method of thrombus formation. The experimental apparatus has one orifice pipe that is a simplified model of shear flow in the rotary blood pumps and the stent device. In the first step, the flow in the orifice pipe flow is analyzed by CFD and the shear rate distribution is shown in the case of steady and pulsate flow. In the second step, the thrombus formation process is visualized for constructing the prediction model of thrombus formation. The feature of the experiment is to observe the thrombus formation process by image processing and to quantify the index of thrombus by using blood plasma. Comparing the experimental result with CFD-based shear rate distribution, it is found that the early thrombus is generated at the part where the shear rate of the orifices is high, and the formation speed is dependent on the gradient of shear rate.